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      Injection of Melatonin into Cisterna Magna Increases Concentration of 3´, 5´ Cyclic Guanosine Monophosphate in Cerebrospinal Fluid

      Neuroendocrinology

      S. Karger AG

      Cerebrospinal fluid, cGMP, Melatonin

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          Abstract

          Rabbits were anesthetized with urethane and were given intracisternal injections of the following substances: adrenocorticotropin, β-melanocyte stimulating hormone, choroid plexus peptide ΠF, epinephrine, serotonin, histamine, oxytocin, lysine and arginine vasopressins, acetylcholine and melatonin. The effects on the concentration of 3’, 5’ cyclic guanosine monophosphate (cGMP) in cerebrospinal fluid were then measured. Only melatonin and acetylcholine caused a significant (p < 0.05) effect on cGMP concentration. Both agents increased the nucleotide’s concentration within 30 min. Melatonin was about 1,000 times more potent than acetylcholine; the minimal effective doses were 1 µg and 1,000 µg, respectively.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1976
          1976
          20 March 2008
          : 20
          : 3
          : 235-242
          Affiliations
          Department of Medicine, Emory University School of Medicine, Atlanta, Ga.
          Article
          122487 Neuroendocrinology 1976;20:235–242
          10.1159/000122487
          183165
          © 1976 S. Karger AG, Basel

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          Page count
          Pages: 8
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