Robust HCV Genotype 3a Infectious Cell Culture System Permits Identification of Escape Variants With Resistance to Sofosbuvir.

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Abstract

Direct-acting antivirals (DAAs) effectively eradicate chronic hepatitis C virus (HCV) infection, although HCV genotype 3a is less responsive to these drugs. We aimed to develop genotype 3a infectious cultures and study the effects of inhibitors of NS5A and NS5B and resistance to sofosbuvir-the only nucleotide analog approved for treatment of chronic HCV infection.

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Journal

Journal ID (iso-abbrev): Gastroenterology

Title: Gastroenterology

Publisher: Elsevier BV

ISSN (Electronic): 1528-0012

ISSN (Print): 0016-5085

Publication date (Electronic): Nov 2016

Volume: 151

Issue: 5

Affiliations

[1 ] Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

[2 ] Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Hvidovre Hospital and Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: jbukh@sund.ku.dk.

Article

Publisher Item ID: S0016-5085(16)34809-0

DOI: 10.1053/j.gastro.2016.07.013

PubMed ID: 27453546

SO-VID: 184fa35a-1392-425d-9a2b-0746431ea8a5

History

Keywords: Liver Disease,NUC,Drug Evasion,In Vitro

Data availability:

Keywords: Liver Disease, NUC, Drug Evasion, In Vitro

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