A suicide note from Alzheimer disease neurons?

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Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease.

Qing Guo, Weiming Fu, Jun Xie … (1998)

Prostate apoptosis response-4 (Par-4) is a protein containing both a leucine zipper and a death domain that was isolated by differential screening for genes upregulated in prostate cancer cells undergoing apoptosis. Par-4 is expressed in the nervous system, where its function is unknown. In Alzheimer disease (AD), neurons may die by apoptosis, and amyloid beta-protein (A beta) may play a role in this. We report here that Par-4 expression is increased in vulnerable neurons in AD brain and is induced in cultured neurons undergoing apoptosis. Blockade of Par-4 expression or function prevented neuronal apoptosis induced by Ab and trophic factor withdrawal. Par-4 expression was enhanced, and mitochondrial dysfunction and apoptosis exacerbated, in cells expressing presenilin-1 mutations associated with early-onset inherited AD.

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Journal

Title: Nature Medicine

Abbreviated Title: Nat Med

Publisher: Springer Nature

ISSN (Print): 1078-8956

Publication date Created: August 1998

Publication date (Print): August 1998

Volume: 4

Issue: 8

Pages: 897-898

Article

DOI: 10.1038/nm0898-897

SO-VID: 18501494-7878-4d3b-a419-0ab362df4ce7

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