CD8+ T-cells contribute to lesion stabilization in advanced atherosclerosis by limiting macrophage content and CD4+ T-cell responses.

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Abstract

T lymphocytes play an important role in atherosclerosis development, but the role of the CD8+ T-cell remains debated, especially in the clinically relevant advanced stages of atherosclerosis development. Here, we set out to determine the role of CD8+ T-cells in advanced atherosclerosis.

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Author and article information

Journal

Journal ID (iso-abbrev): Cardiovasc. Res.

Title: Cardiovascular research

Publisher: Oxford University Press (OUP)

ISSN (Electronic): 1755-3245

ISSN (Print): 0008-6363

Publication date (Electronic): Mar 15 2019

Volume: 115

Issue: 4

Affiliations

[1 ] Division of BioTherapeutics, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Room EE1.17, 2333 CC Leiden, the Netherlands.

[2 ] HMC Westeinde, The Hague, the Netherlands.

[3 ] Department of Immunology, Juntendo University School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan.

Article

Publisher Item ID: 5136024

DOI: 10.1093/cvr/cvy261

PubMed ID: 30335148

SO-VID: 1856e242-fb0c-4891-9575-151d1f8cb406

History

Keywords: Inflammation,CD8+ T-cells,Atherosclerosis

Data availability:

Keywords: Inflammation, CD8+ T-cells, Atherosclerosis

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