Wei-Hua Yue 1 , Hai-Feng Wang , Liang-Dan Sun , Fu-Lei Tang , Zhong-Hua Liu , Hong-Xing Zhang , Wen-Qiang Li , Yan-Ling Zhang , Yang Zhang , Cui-Cui Ma , Bo Du , Li-Fang Wang , Yun-Qing Ren , Yong-Feng Yang , Xiao-Feng Hu , Yi Wang , Wei Deng , Li-Wen Tan , Yun-Long Tan , Qi Chen , Guang-Ming Xu , Gui-Gang Yang , Xian-bo Zuo , Hao Yan , Yan-Yan Ruan , Tian-Lan Lu , Xue Han , Xiao-Hong Ma , Yan Wang , Li-Wei Cai , Chao Jin , Hong-Yan Zhang , Jun Yan , Wei-Feng Mi , Xian-Yong Yin , Wen-Bin Ma , Qi Liu , Lan Kang , Wei Sun , Cheng-Ying Pan , Mei Shuang , Fu-De Yang , Chuan-Yue Wang , Jian-Li Yang , Ke-Qing Li , Xin Ma , Ling-Jiang Li , Xin Yu , Qi-Zhai Li , Xun Huang , Lu-Xian Lv , Tao Li , Guo-Ping Zhao , Wei Huang , Xue-Jun Zhang , Dai Zhang
Oct 30 2011
To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 × 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 × 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 × 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 × 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 × 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 × 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.