Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.

Abstract

To identify susceptibility loci for schizophrenia, we performed a two-stage genome-wide association study (GWAS) of schizophrenia in the Han Chinese population (GWAS: 746 individuals with schizophrenia and 1,599 healthy controls; validation: 4,027 individuals with schizophrenia and 5,603 healthy controls). We identified two susceptibility loci for schizophrenia at 6p21-p22.1 (rs1233710 in an intron of ZKSCAN4, P(combined) = 4.76 × 10(-11), odds ratio (OR) = 0.79; rs1635 in an exon of NKAPL, P(combined) = 6.91 × 10(-12), OR = 0.78; rs2142731 in an intron of PGBD1, P(combined) = 5.14 × 10(-10), OR = 0.79) and 11p11.2 (rs11038167 near the 5' UTR of TSPAN18, P(combined) = 1.09 × 10(-11), OR = 1.29; rs11038172, P(combined) = 7.21 × 10(-10), OR = 1.25; rs835784, P(combined) = 2.73 × 10(-11), OR = 1.27). These results add to previous evidence of susceptibility loci for schizophrenia at 6p21-p22.1 in the Han Chinese population. We found that NKAPL and ZKSCAN4 were expressed in postnatal day 0 (P0) mouse brain. These findings may lead to new insights into the pathogenesis of schizophrenia.

Journal

Journal ID (iso-abbrev): Nat Genet

Title: Nature genetics

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1546-1718

ISSN (Print): 1061-4036

Publication date (Electronic): Oct 30 2011

Volume: 43

Issue: 12

Affiliations

[1 ] Institute of Mental Health, Peking University, Beijing, China.

Article

Publisher Item ID: ng.979

DOI: 10.1038/ng.979

PubMed ID: 22037552

SO-VID: 186d4c1c-1dd1-4db8-99b4-3153dced6a41