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      Nephrotoxicity of Radiocontrast Media in Ischemic Renal Failure in Rabbits

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          Abstract

          Ischemic renal failure was produced in rabbits by occluding the renal arteries for 90 min. Group 1 (n = 8) received radiocontrast media at the time of occlusion, group 2 (n = 8) 24 h after occlusion, and group 3 (n = 8) 3 days after occlusion. Group 4 (n = 12) was subjected to ischemic injury alone, group 5 (n =4) served as sham-operated controls and group 6 (n = 4) did not undergo surgery but received radiocontrast media. Serum creatinine concentration in group 1 increased to a greater degree (p < 0.001) than all other groups and did not return to normal during the 8-day observation period. Creatinine concentration in groups 2, 3, 4, and 6 were comparable and significantly increased compared to sham-operated group (p < 0.05). Urinary excretion of alanine aïninopeptidase and N-acetyl-β-glucosaminidase in group 1 was significantly greater than all other groups (p < 0.05). Microscopic analysis indicated tubular necrosis was more prominent in group 1. Radiocontrast media is nephrotoxic and in the setting of ischemic injury may prevent recovery of renal function. Toxicity was dependent on the time of administration since functional impairment was not increased if dye was given 1 or 3 days after ischemic injury.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1982
          1982
          03 December 2008
          : 32
          : 2
          : 113-117
          Affiliations
          aDepartment of Medicine, Clowes Research Laboratory, Indiana University School of Medicine and bLilly Laboratory for Clinical Research, Indianapolis, Ind., USA
          Article
          182829 Nephron 1982;32:113–117
          10.1159/000182829
          6129580
          © 1982 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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