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      Endotoxin recognition and signal transduction by the TLR4/MD2-complex.

      Microbes and Infection / Institut Pasteur

      Animals, Antigens, Surface, metabolism, physiology, Carrier Proteins, Endotoxins, Lipopolysaccharides, pharmacology, Lymphocyte Antigen 96, Membrane Glycoproteins, Receptors, Cell Surface, Signal Transduction, Toll-Like Receptor 4, Toll-Like Receptors

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          Abstract

          Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression.

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          Journal
          15596121
          10.1016/j.micinf.2004.08.015

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