Ultrasound mediated destruction of multifunctional microbubbles for image guided delivery of oxygen and drugs.

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Abstract

We synthesized multifunctional activatible microbubbles (MAMs) for ultrasound mediated delivery of oxygen and drugs with both ultrasound and fluorescence imaging guidance. Oxygen enriched perfluorocarbon (PFC) compound was encapsulated in liposome microbubbles (MBs) by a modified emulsification process. DiI dye was loaded as a model drug. The ultrasound targeted microbubble destruction (UTMD) process was guided by both ultrasonography and fluorescence imaging modalities. The process was validated in both a dialysis membrane tube model and a porcine carotid artery model. Our experiment results show that the UTMD process effectively facilitates the controlled delivery of oxygen and drug at the disease site and that the MAM agent enables ultrasound and fluorescence imaging guidance of the UTMD process. The proposed MAM agent can be potentially used for UTMD-mediated combination therapy in hypoxic ovarian cancer.

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Journal

Journal ID (iso-abbrev): Ultrason Sonochem

Title: Ultrasonics sonochemistry

Publisher: Elsevier BV

ISSN (Electronic): 1873-2828

ISSN (Print): 1350-4177

Publication date (Electronic): Jan 2016

Volume: 28

Affiliations

[1 ] Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; Department of Obstetrics and Gynecology, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.

[2 ] Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; College of Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China.

[3 ] Division of Health & Rehabilitation Sciences, The Ohio State University Medical Center, Columbus, OH 43210, USA.

[4 ] Department of Obstetrics and Gynecology, The Ohio State University Medical Center, Columbus, OH 43210, USA.

[5 ] Department of Biomedical Engineering, The Ohio State University, Columbus, OH 43210, USA; College of Engineering, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: xu.ronald@gmail.com.

Article

Publisher Item ID: S1350-4177(15)00196-0

DOI: 10.1016/j.ultsonch.2015.06.024

PubMed ID: 26384880

SO-VID: 18a57be4-e4a4-4f28-b706-f05699b6fb0b

Keywords: Drug delivery,Fluorescence imaging,Multifunctional microbubbles,Oxygen,Perfluorocarbon,Ultrasound targeted microbubble destruction

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Keywords: Drug delivery, Fluorescence imaging, Multifunctional microbubbles, Oxygen, Perfluorocarbon, Ultrasound targeted microbubble destruction

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