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      Effect of Sairei-to on Prostaglandin E 2-lnduced Phosphatidylinositol Breakdown in Aminonucleoside Nephrotic Rat

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          Abstract

          We describe the effects of Sairei-to, a Chinese herbal medicine, on aminonucleoside-induced nephrotic rats (ANNR), and analyze the urinary excretion of protein and phosphatidylinositol (PI) turnover via prostaglandin E<sub>2</sub> (PGE2) receptors in isolated glomeruli. Sairei-to suppressed urinary excretion of protein and PGE<sub>2</sub> in ANNR, and inhibited acceleration of PI turnover in isolated nephrotic glomeruli. The affected responsiveness of the PI turnover system to PGE<sub>2</sub> in a nephrotic state was presumed to be normalized by Sairei-to. These findings suggest that Sairei-to restores abnormal changes in the PI turnover system in ANNR kidneys, and thereby inhibit excretion of protein into the urine.

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          Author and article information

          Journal
          Journal ID (publisher-id): NEF
          Journal ID (nlm-ta): Nephron
          Journal ID (doi): 10.1159/issn.1660-8151
          Title: Nephron
          Publisher: S. Karger AG
          ISSN (Print): 1660-8151
          ISSN (Electronic): 2235-3186
          Publication date Subscription-year: 1997
          Publication date (Print): 1997
          Publication date (Electronic): 19 December 2008
          Volume: 75
          Issue: 2
          Pages: 208-212
          Affiliations
          Department of Pediatrics, Fukushima Medical College, Fukushima City, Japan
          Article
          Publisher ID: 189533 Other ID: Nephron 1997;75:208–212
          DOI: 10.1159/000189533
          PubMed ID: 9041543
          SO-VID: 18b04f1b-0670-4da7-92c6-fc7055452557
          Copyright © © 1997 S. Karger AG, Basel
          License:

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          Date accepted : 11 April 1996
          Page count
          Pages: 5
          Categories
          Subject: Original Paper

          ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
          Keywords: Phosphatidylinositol turnover,PGE2 receptor,Sairei-to,Chinese herbal medicine,Nephrotic syndrome
          Data availability:
          ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
          Keywords: Phosphatidylinositol turnover, PGE2 receptor, Sairei-to, Chinese herbal medicine, Nephrotic syndrome

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