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      Effect of urbanisation on the relationship between total serum IgE and asthma

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          Abstract

          It is unclear if the relationship of total serum IgE with asthma varies with degree of urbanisation. We hypothesised that the relationship of total serum IgE to asthma is more pronounced in an urban versus a rural environment.

          We enrolled 1441 children aged 13–15 years in a peri-urban shanty town in Lima, Peru (n=725) and 23 villages in rural Tumbes, Peru (n=716). We asked participants about asthma and allergy symptoms, environmental exposures and sociodemographics; and performed spirometry, and exhaled nitric oxide and allergy skin testing. We obtained blood for total serum IgE in 1143 (79%) participants.

          Geometric means for total serum IgE were higher in Lima versus Tumbes (262 versus 192 kU·L −1; p<0.001). The odds of asthma increased by factors of 1.6 (95% CI 1.3–2.0) versus 1.4 (95% CI 0.9–2.1) per log unit increase in total serum in Lima versus Tumbes, respectively. Atopy was an effect modifier of the relationship of total serum IgE on asthma. Among atopics and non-atopics, the odds of asthma increased by a factor of 2.0 (95% CI 1.5–2.7) and 1.0 (95% CI 0.7–1.4) per log unit increase in total serum IgE, respectively.

          Total serum IgE was associated with atopic asthma but not with non-atopic asthma. Urbanisation did not appear to be an effect modifier of this relationship.

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          Author and article information

          Journal
          8803460
          3682
          Eur Respir J
          Eur. Respir. J.
          The European respiratory journal
          0903-1936
          1399-3003
          15 February 2017
          26 July 2012
          May 2013
          10 March 2017
          : 41
          : 5
          : 1074-1081
          Affiliations
          [* ]Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD
          [# ]Program in Global Disease Epidemiology and Control, Dept of International Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
          [§ ]Division of Allergy and Clinical Immunology, School of Medicine, Johns Hopkins University, Baltimore, MD
          [** ]Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA
          [## ]Dept of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
          []CRONICAS Center of Excellence for Chronic Disease Research, Universidad Peruana Cayetano Heredia, Lima
          [+ ]Asociación Benéfica PRISMA, Lima
          [ƒ ]Departamento de Microbiologia, Universidad Peruana Cayetano Heredia, Lima, Peru
          Author notes
          CORRESPONDENCE: W. Checkley, Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University,1800 Orleans Street, Suite 9121, Baltimore, MD 21205, USA, wcheckl1@ 123456jhmi.edu
          Article
          PMC5345487 PMC5345487 5345487 nihpa850837
          10.1183/09031936.00025512
          5345487
          22835619
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          Article

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