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The cerebellum and pain: Passive integrator or active participator?
Author(s):
Eric A. Moulton
,
Jeremy D. Schmahmann
,
Lino Becerra
,
David Borsook
Publication date
Created:
October 2010
Publication date
(Print):
October 2010
Journal:
Brain Research Reviews
Publisher:
Elsevier BV
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PMC
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Abstract
The cerebellum is classically considered to be a brain region involved in motor processing, but it has also been implicated in non-motor, and even cognitive, functions. Though previous research suggests that the cerebellum responds to noxious stimuli, its specific role during pain is unclear. Pain is a multidimensional experience that encompasses sensory discriminative, affective motivational, and cognitive evaluative components. Cerebellar involvement during the processing of pain could thus potentially reflect a number of different functional processes. This review will summarize the animal and human research to date that indicates that (1) primary afferents conduct nociceptive (noxious) input to the cerebellum, (2) electrical and pharmacological stimulation of the cerebellum can modulate nociceptive processing, and (3) cerebellar activity occurs during the presence of acute and chronic pain. Possible functional roles for the cerebellum relating to pain will be considered, including perspectives relating to emotion, cognition, and motor control in response to pain. Copyright © 2010 Elsevier B.V. All rights reserved.
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Author and article information
Journal
Title:
Brain Research Reviews
Abbreviated Title:
Brain Research Reviews
Publisher:
Elsevier BV
ISSN (Print):
01650173
Publication date Created:
October 2010
Publication date (Print):
October 2010
Volume
: 65
Issue
: 1
Pages
: 14-27
Article
DOI:
10.1016/j.brainresrev.2010.05.005
PMC ID:
2943015
PubMed ID:
20553761
SO-VID:
18d166aa-dd4a-4617-814e-b6ca7fedc78f
Copyright ©
© 2010
License:
https://www.elsevier.com/tdm/userlicense/1.0/
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