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Deoxyelephantopin ameliorates lipopolysaccharides (LPS)-induced memory impairments in rats: Evidence for its anti-neuroinflammatory properties
August 2018
August 2018
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Abstract
<p class="first" id="d10069626e85">Neuroinflammation is a critical pathogenic mechanism
of most neurodegenerative disorders
especially, Alzheimer's disease (AD). Lipopolysaccharides (LPS) are known to induce
neuroinflammation which is evident from significant upsurge of pro-inflammatory mediators
in in vitro BV-2 microglial cells and in vivo animal models. In present study, we
investigated anti-neuroinflammatory properties of deoxyelephantopin (DET) isolated
from Elephantopus scaber in LPS-induced neuroinflammatory rat model.
</p>