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Abstract
Mouse sarcoma 180 (S-180) solid and ascites tumor cells were treated in vivo and in
vitro with withaferin A and observed with the electron microscope. The compound was
found to effect this spindle microtubules of cells in metaphase. An interesting finding
was the double membranes surrounding the chromosomes in the treated cells; probably
the nuclei were reconstructed directly from the metaphase stage in the in vivo withaferin
A-treated cells. In addition the membranes of the cells in interphase were affected
by in vivo or in vitro treatment with the compound.