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      Developmental Patterns of Tyrosine Hydroxylase Activity in Discrete Central Nervous System Regions and Serum LH and Prolactin in the Prepubertal Rat

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          Abstract

          Changes in tyrosine hydroxylase (TH) activity in the whole hypothalamus and discrete nuclear regions of the limbic system were observed to occur from 10 to 40 days of age in the female rat. In the whole hypothalamus, TH activity increased between 10 and 30 days of age then decreased at 40 days of age. In the preoptic (POA) and suprachiasmatic nuclear areas (SCN), TH activity increased to peak values at 20 days then declined to baseline values at 25 days. However, an increase in TH activity of SCN was again noted at 39 days of age. TH activity in the amygdala area (AMYG) increased to peak values at 25 and 30 days with a return to baseline levels at 35 days, while in the median eminence (ME), TH activity increased at 20 days and remained elevated through 39 days of age. These results show that temporally distinct changes in TH activity occur during development in various areas of the brain. These changes may represent maturation of neuronal control systems known to be involved in adult reproductive function.

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          Author and article information

          Journal
          NEN
          Neuroendocrinology
          10.1159/issn.0028-3835
          Neuroendocrinology
          S. Karger AG
          0028-3835
          1423-0194
          1984
          1984
          28 March 2008
          : 38
          : 2
          : 134-138
          Affiliations
          Department of Physiology and Biophysics, University of Louisville School of Medicine, Louisville, Ky., USA
          Article
          123880 Neuroendocrinology 1984;38:134–138
          10.1159/000123880
          6144058
          © 1984 S. Karger AG, Basel

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          Page count
          Pages: 5
          Categories
          Original Paper

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