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      Serum zonulin is elevated in women with polycystic ovary syndrome and correlates with insulin resistance and severity of anovulation.

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          Abstract

          Evidence suggests that increased gut permeability may be associated with polycystic ovary syndrome (PCOS). Human zonulin is currently the only physiological mediator known to reversibly regulate gut permeability by disassembling intestinal tight junctions. So far, no data on serum zonulin levels in patients with PCOS are available. This study aimed to determine circulating serum zonulin levels in women with PCOS and discuss the relationship between zonulin, insulin resistance, and menstrual disorders in this group.

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          Author and article information

          Journal
          Eur. J. Endocrinol.
          European journal of endocrinology
          BioScientifica
          1479-683X
          0804-4643
          Jan 2015
          : 172
          : 1
          Affiliations
          [1 ] Department of EndocrinologyXiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, ChinaSchool of NursingUniversity of California Los Angeles, Los Angeles, California, USA drdmzhang@hotmail.com.
          [2 ] Department of EndocrinologyXiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, Hunan, ChinaSchool of NursingUniversity of California Los Angeles, Los Angeles, California, USA.
          Article
          EJE-14-0589
          10.1530/EJE-14-0589
          25336505
          1917cf7e-ba32-46cb-ba87-dc731bd63783
          History

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