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      Advances in Alzheimer's Diagnosis and Therapy: The Implications of Nanotechnology.

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          Abstract

          Alzheimer's disease (AD) is a type of dementia that causes major issues for patients' memory, thinking, and behavior. Despite efforts to advance AD diagnostic and therapeutic tools, AD remains incurable due to its complex and multifactorial nature and lack of effective diagnostics/therapeutics. Nanoparticles (NPs) have demonstrated the potential to overcome the challenges and limitations associated with traditional diagnostics/therapeutics. Nanotechnology is now offering new tools and insights to advance our understanding of AD and eventually may offer new hope to AD patients. Here, we review the key roles of nanotechnologies in the recent literature, in both diagnostic and therapeutic aspects of AD, and discuss how these achievements may improve patient prognosis and quality of life.

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          Author and article information

          Journal
          Trends Biotechnol.
          Trends in biotechnology
          Elsevier BV
          1879-3096
          0167-7799
          Oct 2017
          : 35
          : 10
          Affiliations
          [1 ] Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 75147, Iran; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran 13169-43551, Iran.
          [2 ] Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA.
          [3 ] Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
          [4 ] Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
          [5 ] Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 13169-43551, Iran. Electronic address: mmahmoudi@bwh.harvard.edu.
          [6 ] Neurosciences Institute and Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: george.perry@utsa.edu.
          Article
          S0167-7799(17)30130-0
          10.1016/j.tibtech.2017.06.002
          28666544

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