Advances in Alzheimer's Diagnosis and Therapy: The Implications of Nanotechnology.

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Abstract

Alzheimer's disease (AD) is a type of dementia that causes major issues for patients' memory, thinking, and behavior. Despite efforts to advance AD diagnostic and therapeutic tools, AD remains incurable due to its complex and multifactorial nature and lack of effective diagnostics/therapeutics. Nanoparticles (NPs) have demonstrated the potential to overcome the challenges and limitations associated with traditional diagnostics/therapeutics. Nanotechnology is now offering new tools and insights to advance our understanding of AD and eventually may offer new hope to AD patients. Here, we review the key roles of nanotechnologies in the recent literature, in both diagnostic and therapeutic aspects of AD, and discuss how these achievements may improve patient prognosis and quality of life.

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Journal

Journal ID (iso-abbrev): Trends Biotechnol.

Title: Trends in biotechnology

Publisher: Elsevier BV

ISSN (Electronic): 1879-3096

ISSN (Print): 0167-7799

Publication date (Electronic): Oct 2017

Volume: 35

Issue: 10

Affiliations

[1 ] Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 75147, Iran; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran 13169-43551, Iran.

[2 ] Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA.

[3 ] Department of Cell Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

[4 ] Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

[5 ] Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 13169-43551, Iran. Electronic address: mmahmoudi@bwh.harvard.edu.

[6 ] Neurosciences Institute and Department of Biology, College of Sciences, University of Texas at San Antonio, San Antonio, TX, USA. Electronic address: george.perry@utsa.edu.

Article

Publisher Item ID: S0167-7799(17)30130-0

DOI: 10.1016/j.tibtech.2017.06.002

PubMed ID: 28666544

SO-VID: 191d997a-8c0f-4868-a937-ca00ca1141e0

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