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      Forest Volatile Organic Compounds and Their Effects on Human Health: A State-of-the-Art Review

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          Abstract

          The aim of this research work is to analyze the chemistry and diversity of forest VOCs (volatile organic compounds) and to outline their evidence-based effects on health. This research work was designed as a narrative overview of the scientific literature. Inhaling forest VOCs like limonene and pinene can result in useful antioxidant and anti-inflammatory effects on the airways, and the pharmacological activity of some terpenes absorbed through inhalation may be also beneficial to promote brain functions by decreasing mental fatigue, inducing relaxation, and improving cognitive performance and mood. The tree composition can markedly influence the concentration of specific VOCs in the forest air, which also exhibits cyclic diurnal variations. Moreover, beneficial psychological and physiological effects of visiting a forest cannot be solely attributed to VOC inhalation but are due to a global and integrated stimulation of the five senses, induced by all specific characteristics of the natural environment, with the visual component probably playing a fundamental role in the overall effect. Globally, these findings can have useful implications for individual wellbeing, public health, and landscape design. Further clinical and environmental studies are advised, since the majority of the existing evidence is derived from laboratory findings.

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          The Model of Emissions of Gases and Aerosols from Nature version 2.1 (MEGAN2.1): an extended and updated framework for modeling biogenic emissions

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            Mechanisms of plant defense against insect herbivores.

            Plants respond to herbivory through various morphological, biochemicals, and molecular mechanisms to counter/offset the effects of herbivore attack. The biochemical mechanisms of defense against the herbivores are wide-ranging, highly dynamic, and are mediated both by direct and indirect defenses. The defensive compounds are either produced constitutively or in response to plant damage, and affect feeding, growth, and survival of herbivores. In addition, plants also release volatile organic compounds that attract the natural enemies of the herbivores. These strategies either act independently or in conjunction with each other. However, our understanding of these defensive mechanisms is still limited. Induced resistance could be exploited as an important tool for the pest management to minimize the amounts of insecticides used for pest control. Host plant resistance to insects, particularly, induced resistance, can also be manipulated with the use of chemical elicitors of secondary metabolites, which confer resistance to insects. By understanding the mechanisms of induced resistance, we can predict the herbivores that are likely to be affected by induced responses. The elicitors of induced responses can be sprayed on crop plants to build up the natural defense system against damage caused by herbivores. The induced responses can also be engineered genetically, so that the defensive compounds are constitutively produced in plants against are challenged by the herbivory. Induced resistance can be exploited for developing crop cultivars, which readily produce the inducible response upon mild infestation, and can act as one of components of integrated pest management for sustainable crop production.
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              Writing narrative literature reviews for peer-reviewed journals: secrets of the trade.

              To describe and discuss the process used to write a narrative review of the literature for publication in a peer-reviewed journal. Publication of narrative overviews of the literature should be standardized to increase their objectivity. In the past decade numerous changes in research methodology pertaining to reviews of the literature have occurred. These changes necessitate authors of review articles to be familiar with current standards in the publication process. Narrative overview of the literature synthesizing the findings of literature retrieved from searches of computerized databases, hand searches, and authoritative texts. An overview of the use of three types of reviews of the literature is presented. Step by step instructions for how to conduct and write a narrative overview utilizing a 'best-evidence synthesis' approach are discussed, starting with appropriate preparatory work and ending with how to create proper illustrations. Several resources for creating reviews of the literature are presented and a narrative overview critical appraisal worksheet is included. A bibliography of other useful reading is presented in an appendix. Narrative overviews can be a valuable contribution to the literature if prepared properly. New and experienced authors wishing to write a narrative overview should find this article useful in constructing such a paper and carrying out the research process. It is hoped that this article will stimulate scholarly dialog amongst colleagues about this research design and other complex literature review methods.
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                Author and article information

                Journal
                Int J Environ Res Public Health
                Int J Environ Res Public Health
                ijerph
                International Journal of Environmental Research and Public Health
                MDPI
                1661-7827
                1660-4601
                07 September 2020
                September 2020
                : 17
                : 18
                : 6506
                Affiliations
                [1 ]Terme di Monticelli, 43022 Monticelli Terme PR, Italy
                [2 ]Institute of Public Health, University of Parma, 43125 Parma PR, Italy
                [3 ]CERFIT, Careggi University Hospital, 50139 Firenze FI, Italy; donelli.davide@ 123456gmail.com (D.D.); valentina.maggini@ 123456unifi.it (V.M.); fabio.firenzuoli@ 123456unifi.it (F.F.)
                [4 ]AUSL-IRCCS Reggio Emilia, 42122 Reggio Emilia RE, Italy
                [5 ]Binini Partners S.r.l. Engineering and Architecture, 42121 Reggio Emilia RE, Italy; grazia.barbieri.1994@ 123456gmail.com
                [6 ]European Herbal and Traditional Medicine Practitioners Association (EHTPA), Norwich NR3 1HG, UK; marco@ 123456infoerbe.it
                Author notes
                Author information
                https://orcid.org/0000-0002-7895-2840
                https://orcid.org/0000-0003-1911-2021
                Article
                ijerph-17-06506
                10.3390/ijerph17186506
                7559006
                32906736
                1935982e-3720-4958-98c8-b505ba6d1f70
                © 2020 by the authors.

                Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ( http://creativecommons.org/licenses/by/4.0/).

                History
                : 09 August 2020
                : 04 September 2020
                Categories
                Review

                Public health
                biogenic volatile organic compounds,phytoncides,pinene,limonene,forest,public health,preventive medicine,review

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