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      High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery

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          Abstract

          Analysis of pharmaceutical and natural compounds and newer drugs is commonly used in all the stages of drug discovery and development process. High-performance thin layer chromatography is one of the sophisticated instrumental techniques based on the full capabilities of thin layer chromatography. The advantages of automation, scanning, full optimization, selective detection principle, minimum sample preparation, hyphenation, and so on enable it to be a powerful analytical tool for chromatographic information of complex mixtures of pharmaceuticals, natural products, clinical samples, food stuffs, and so on.

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          Natural products to drugs: natural product-derived compounds in clinical trials.

          John S. Butler (2008)
          Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural product-derived compounds for which clinical trials have been halted or discontinued since 2005. Also discussed are natural product-derived drugs launched since 2005, new natural product templates and late-stage development candidates.
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            Automation of a surface sampling probe/electrospray mass spectrometry system.

            Tyler Ford, Vilmos Kertesz, Johannes van Goudoever (2005)
            An image analysis automation concept and the associated software (HandsFree TLC/MS) were developed to control the surface sampling probe-to-surface distance during operation of a surface sampling electrospray system. This automation system enables both "hands-free" formation of the liquid microjunction used to sample material from the surface and hands-free reoptimization of the microjunction thickness during a surface scan to achieve a fully automated surface sampling system. The image analysis concept and the practical implementation of the monitoring and automated adjustment of the sampling probe-to-surface distance (i.e., liquid microjunction thickness) are presented. The added capabilities for the preexisting surface sampling electrospray system afforded through this software control are illustrated by an example of automated scanning of multiple development lanes on a reversed-phase C8 TLC plate and by imaging inked lettering on a paper surface. The post data acquisition processing and data display aspects of the software package are also discussed.
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              High performance thin layer chromatography (HPTLC), an improved technique for screening lichen substances

              Jan-Eric Mattsson, Ulf Arup, Stefan Ekman … (1993)
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                Author and article information

                Journal
                Journal ID (nlm-ta): Pharm Methods
                Journal ID (iso-abbrev): Pharm Methods
                Journal ID (publisher-id): PMeth
                Title: Pharmaceutical Methods
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 2229-4708
                ISSN (Electronic): 2229-4716
                Publication date (Print): Apr-Jun 2011
                Volume: 2
                Issue: 2
                Pages: 71-75
                Affiliations
                [1]Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia
                Author notes
                Address for correspondence: Dr. Mueen Ahmed, Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia. E-mail: mueen.ahmed@ 123456gmail.com
                Article
                Publisher ID: PMeth-2-71
                DOI: 10.4103/2229-4708.84436
                PMC ID: 3658041
                PubMed ID: 23781433
                SO-VID: 193f9a55-003e-42d2-9365-6409eed8ced3
                Copyright © Copyright: © Pharmaceutical Methods
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Subject: Symposium - HPTLC

                Keywords: drug discovery,hptlc,natural products,planar chromatography
                Data availability:
                Keywords: drug discovery, hptlc, natural products, planar chromatography

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