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      Pharmacokinetics and Pharmacodynamics of Captopril in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

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          Pharmacokinetics and pharmacodynamics of captopril were studied in 5 continuous ambulatory peritoneal dialysis (CAPD) patients (including 2 hypertensive patients) after single oral administration of 50 mg captopril. The pharmacokinetic parameters for plasma free unchanged captopril were time to maximal concentration 1.1 ± 0.3 h, maximal plasma concentration 387 ± 75 ng·ml<sup>-1</sup>, elimination half-life 1.0 ± 0.3 h, and the area under the concentration-time curve 711 ± 144 ng·h•ml<sup>-1</sup>. For plasma total captopril (the sum of free unchanged captopril and its disulfide compounds) the values were time to maximal concentration 3.5 ± 0.6 h and maximal plasma concentration 2,777 ± 429 ng·ml<sup>-1</sup>. Captopril was detected in the dialysis fluid in all CAPD patients. Blood pressures in the 2 hypertensive CAPD patients were lower at 24 h after than before captopril administration. These results suggest that captopril may be eliminated by CAPD. In addition, there is a possibility that the antihypertensive effects of captopril may be prolonged in hypertensive CAPD patients.

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          S. Karger AG
          05 December 2008
          : 44
          : 4
          : 324-328
          Departments of aClinical Pharmacology and bUrology, Oita National Medical School, and cProduct Development Laboratories, Sankyo Company Ltd., Oita, Japan
          184014 Nephron 1986;44:324–328
          © 1986 S. Karger AG, Basel

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          Pages: 5
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