There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
The efficient and novel bifunctional organocatalyst for the enantioselective aza-Morita-Baylis-Hillman
(aza-MBH) reaction has been established with (S)-3-(N-isopropyl-N-3-pyridinylaminomethyl)BINOL
for the first time. The reaction proved to be deeply influenced by the position of
the Lewis base attached to BINOL. The acid-base-mediated functionalities for the activation
of the substrate and the fixing of conformation of the organocatalyst are harmoniously
performed to promote the reaction with high enantiocontrol.