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      Gentamicin Reduces Serum ACE Activity in Patients with Normal Kidney Function

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          Abstract

          Aims: We evaluated serum angiotensin-converting enzyme (ACE) as an indicator of gentamicin toxicity and compared it with N-acetyl-β- D-glucosaminidase (NAG) and creatinine. Methods: 20 bone fracture in-patients receiving gentamicin 80 mg TDS for 3 days. Subjects had normal kidney function and had no history or sign of hypertension. Serum and urine samples were collected before and 3 days after drug administration. Samples analyzed for ACE, NAG, BUN, creatinine, sodium, and potassium. Results: Our results showed that urine NAG activity increased significantly at the 3rd day. Serum creatinine level and glomerular filtration rate (GFR) while still at a normal range showed slight but significant changes at this time. This may indicate some renal damage. Serum ACE activity decreased significantly at the 3rd day. Conclusion: These results indicate serum ACE can be used as a good indicator of renal damage in patients receiving gentamicin.

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          Most cited references 3

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          Angiotensin-converting enzyme and the regulation of vasoactive peptides.

           R Soffer (1975)
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            Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome

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              Antagonism between T3 and amiodarone on the contractility and the density of β-adrenoceptors of chicken cardiac myocytes

               Y. Yin,  R Vassy,  P Nicolas (1994)
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                Author and article information

                Journal
                AJN
                Am J Nephrol
                10.1159/issn.0250-8095
                American Journal of Nephrology
                S. Karger AG
                0250-8095
                1421-9670
                2002
                December 2002
                07 October 2002
                : 22
                : 5-6
                : 487-490
                Affiliations
                aDepartment of Pharmacology, Institute of Medicinal Plants and Natural Products, ACECR, bNephrology Section, Rassoul Akram Medical Center, and cDepartment of Pharmacology, Iran University of Medical Sciences, Tehran, Iran
                Article
                65282 Am J Nephrol 2002;22:487–490
                10.1159/000065282
                12381948
                © 2002 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 2, Tables: 2, References: 26, Pages: 4
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/65282
                Categories
                Clinical Study

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