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      Gentamicin Reduces Serum ACE Activity in Patients with Normal Kidney Function

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          Aims: We evaluated serum angiotensin-converting enzyme (ACE) as an indicator of gentamicin toxicity and compared it with N-acetyl-β- D-glucosaminidase (NAG) and creatinine. Methods: 20 bone fracture in-patients receiving gentamicin 80 mg TDS for 3 days. Subjects had normal kidney function and had no history or sign of hypertension. Serum and urine samples were collected before and 3 days after drug administration. Samples analyzed for ACE, NAG, BUN, creatinine, sodium, and potassium. Results: Our results showed that urine NAG activity increased significantly at the 3rd day. Serum creatinine level and glomerular filtration rate (GFR) while still at a normal range showed slight but significant changes at this time. This may indicate some renal damage. Serum ACE activity decreased significantly at the 3rd day. Conclusion: These results indicate serum ACE can be used as a good indicator of renal damage in patients receiving gentamicin.

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          Most cited references 3

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          Angiotensin-converting enzyme and the regulation of vasoactive peptides.

           R Soffer (1975)
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            Angiotensin I-converting enzyme activity in puromycin aminonucleoside-nephrotic syndrome

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              Antagonism between T3 and amiodarone on the contractility and the density of β-adrenoceptors of chicken cardiac myocytes

               Y. Yin,  R Vassy,  P Nicolas (1994)

                Author and article information

                Am J Nephrol
                American Journal of Nephrology
                S. Karger AG
                December 2002
                07 October 2002
                : 22
                : 5-6
                : 487-490
                aDepartment of Pharmacology, Institute of Medicinal Plants and Natural Products, ACECR, bNephrology Section, Rassoul Akram Medical Center, and cDepartment of Pharmacology, Iran University of Medical Sciences, Tehran, Iran
                65282 Am J Nephrol 2002;22:487–490
                © 2002 S. Karger AG, Basel

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                Figures: 2, Tables: 2, References: 26, Pages: 4
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