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Animal model of depression: Pharmacological sensitivity of a hedonic deficit
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Abstract
A reduction in sucrose and saccharine consumption following chronic stress is reported
for the rat. This deficit may be related to consummatory deficits seen in endogenous
depression. To further examine this state pharmacologically, stressed rats were treated
with the antidepressant imipramine. Despite a general absence of appetitive effects
(or in some cases mild anorexia) imipramine significantly restored saccharine consumption
in a variety of tests. The pharmacological similarity of the deficit to the changes
accompanying affective disorders further supports the potential applicability of the
chronic stress model.