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      Biomedical Alloys and Physical Surface Modifications: A Mini-Review

      , ,
      Materials
      MDPI AG

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          Abstract

          Biomedical alloys are essential parts of modern biomedical applications. However, they cannot satisfy the increasing requirements for large-scale production owing to the degradation of metals. Physical surface modification could be an effective way to enhance their biofunctionality. The main goal of this review is to emphasize the importance of the physical surface modification of biomedical alloys. In this review, we compare the properties of several common biomedical alloys, including stainless steel, Co–Cr, and Ti alloys. Then, we introduce the principle and applications of some popular physical surface modifications, such as thermal spraying, glow discharge plasma, ion implantation, ultrasonic nanocrystal surface modification, and physical vapor deposition. The importance of physical surface modifications in improving the biofunctionality of biomedical alloys is revealed. Future studies could focus on the development of novel coating materials and the integration of various approaches.

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          Most cited references154

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          Surface modification of titanium, titanium alloys, and related materials for biomedical applications

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            Development of new metallic alloys for biomedical applications.

            New low modulus β-type titanium alloys for biomedical applications are still currently being developed. Strong and enduring β-type titanium alloy with a low Young's modulus are being investigated. A low modulus has been proved to be effective in inhibiting bone atrophy, leading to good bone remodeling in a bone fracture model in the rabbit tibia. Very recently β-type titanium alloys with a self-tunable modulus have been proposed for the construction of removable implants. Nickel-free low modulus β-type titanium alloys showing shape memory and super elastic behavior are also currently being developed. Nickel-free stainless steel and cobalt-chromium alloys for biomedical applications are receiving attention as well. Newly developed zirconium-based alloys for biomedical applications are proving very interesting. Magnesium-based or iron-based biodegradable biomaterials are under development. Further, tantalum, and niobium and its alloys are being investigated for biomedical applications. The development of new metallic alloys for biomedical applications is described in this paper.
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              Designing materials for biology and medicine.

              Biomaterials have played an enormous role in the success of medical devices and drug delivery systems. We discuss here new challenges and directions in biomaterials research. These include synthetic replacements for biological tissues, designing materials for specific medical applications, and materials for new applications such as diagnostics and array technologies.
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                Author and article information

                Contributors
                Journal
                MATEG9
                Materials
                Materials
                MDPI AG
                1996-1944
                January 2022
                December 22 2021
                : 15
                : 1
                : 66
                Article
                10.3390/ma15010066
                197d05f9-a81a-4b56-8d27-21f310ba6c55
                © 2021

                https://creativecommons.org/licenses/by/4.0/

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