16
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Neuromodulation interventions for addictive disorders: challenges, promise, and roadmap for future research

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Neuromodulatory interventions – such as deep brain stimulation, transcranial magnetic stimulation, and transcranial direct current stimulation – hold promise for the targeting and remodelling of circuit dysfunctions in addiction. Spagnolo and Goldman review the literature on neuromodulation in addiction disorders, highlighting recent developments and limitations, and topics for future studies.

          Abstract

          Addictive disorders are a major public health concern, associated with high relapse rates, significant disability and substantial mortality. Unfortunately, current interventions are only modestly effective. Preclinical studies as well as human neuroimaging studies have provided strong evidence that the observable behaviours that characterize the addiction phenotype, such as compulsive drug consumption, impaired self-control, and behavioural inflexibility, reflect underlying dysregulation and malfunction in specific neural circuits. These developments have been accompanied by advances in neuromodulation interventions, both invasive as deep brain stimulation, and non-invasive such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation. These interventions appear particularly promising as they may not only allow us to probe affected brain circuits in addictive disorders, but also seem to have unique therapeutic applications to directly target and remodel impaired circuits. However, the available literature is still relatively small and sparse, and the long-term safety and efficacy of these interventions need to be confirmed. Here we review the literature on the use of neuromodulation in addictive disorders to highlight progress limitations with the aim to suggest future directions for this field.

          Related collections

          Author and article information

          Journal
          Brain
          Brain
          brainj
          Brain
          Oxford University Press
          0006-8950
          1460-2156
          May 2017
          03 December 2016
          03 December 2016
          : 140
          : 5
          : 1183-1203
          Affiliations
          [1 ]1 Office of the Clinical Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
          [2 ]2 Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland, USA
          Author notes
          Correspondence to: Primavera A Spagnolo, MD, Ph.D, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, 10 Center Drive, Room I3471:10CRC, Bethesda MD 20892-9412, USA E-mail: vera.spagnolo@ 123456nih.gov
          Article
          PMC6059187 PMC6059187 6059187 aww284
          10.1093/brain/aww284
          6059187
          28082299
          19a97628-2e23-4823-83f6-2f91720603dc
          Published by Oxford University Press on behalf of the Guarantors of Brain 2016. This work is written by US Government employees and is in the public domain in the United States.
          History
          : 21 March 2016
          : 24 August 2016
          : 12 September 2016
          Page count
          Pages: 21
          Funding
          Funded by: National Institutes of Health 10.13039/100000002
          Award ID: Z99 AA999999/Intramural
          Funded by: NIH HHS/United States
          Award ID: Z99 AA999999/Intramural
          Categories
          Review Article

          transcranial direct current stimulation,transcranial magnetic stimulation,deep brain stimulation,addictive disorders,neuromodulation

          Comments

          Comment on this article