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      Long Noncoding RNAs in Cancer Pathways.

      1 , 2

      Cancer cell

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          Abstract

          Genome-wide cancer mutation analyses are revealing an extensive landscape of functional mutations within the noncoding genome, with profound effects on the expression of long noncoding RNAs (lncRNAs). While the exquisite regulation of lncRNA transcription can provide signals of malignant transformation, we now understand that lncRNAs drive many important cancer phenotypes through their interactions with other cellular macromolecules including DNA, protein, and RNA. Recent advancements in surveying lncRNA molecular mechanisms are now providing the tools to functionally annotate these cancer-associated transcripts, making these molecules attractive targets for therapeutic intervention in the fight against cancer.

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          Author and article information

          Journal
          Cancer Cell
          Cancer cell
          1878-3686
          1535-6108
          Apr 11 2016
          : 29
          : 4
          Affiliations
          [1 ] Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: schmitta@mskcc.org.
          [2 ] Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: howchang@stanford.edu.
          Article
          S1535-6108(16)30092-7 NIHMS770680
          10.1016/j.ccell.2016.03.010
          27070700
          Copyright © 2016 Elsevier Inc. All rights reserved.

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