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      The excretion in urine of four insecticidal carbamates and their phenolic metabolites after oral administration to rats.

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      Archives of toxicology

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          Abstract

          4 insecticidal carbamates: 3-methyl, 5-isopropylphenyl N-methyl-carbamate (Promecarb), 4-methylthio, 3,5 dimethylphenyl N-methylcarbamate (Mesurol), 4-dimethyl-amino, 3,5 dimethylphenyl N-methylcarbamate (Zectran), and 4-benzothienyl N-methyl-carbamate (Mobam) were orally administered to male Wistar rats. The excretion of the unchanged products was followed in 24 hrs urine collections. The corresponding phenols of the different carbamates could be identified as metabolites by gas-chromatography-mass spectrometyr. These metabolites were quantified afterward by gas-liquid chromatography. In all cases only minor quantities of unchanged products and metabolites were excreted in the urine over the 48 hrs after administration.

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          Author and article information

          Journal
          Arch. Toxicol.
          Archives of toxicology
          0340-5761
          0340-5761
          Oct 20 1975
          : 34
          : 2
          Article
          1242891
          19fb562e-4c19-4709-8306-79e4dc0a1dfc
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