Venous Changes in Renal Hypertensive Rats: The Role of Humoral Factors

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

In order to investigate the role of circulating humoral substances in the pathogenesis of venous changes in experimental hypertension, an attempt was made to induce venous changes in rats in parabiosis with two-kidney Goldblatt hypertensive rats. Sham-operated normotensive rats in parabiosis were used as controls. Venous pressure-volume curves were obtained in the pump perfused vascular beds of the lower body of rats by recording the femoral vein pressure rise during rapid infusion of fluid into the inferior vena cava. The water, sodium and potassium content of veins also was measured. Compared to values in normotensive control rats (n = 11), the venous pressure-volume curves of two-kidney Goldblatt hypertensive rats in parabiosis with unoperated rats (n = 13) were shifted in the direction of the pressure axis (p < 0.01), indicating decreased venous capacity. Venous pressure-volume curves in rats in parabiosis with two-kidney Goldblatt hypertensive rats (n = 13) and in rats in parabiosis with sham-operated rats (n = 10) were similar. The venous wall water, sodium and potassium content in two-kidney Goldblatt hypertensive rats (n = 8) and in their unoperated parabiotic mates (n = 8) was increased (p < 0.05) in comparison to that of sham-operated rats in parabiosis (n = 10). These experiments provide evidence for the role of circulating humoral substances in the pathogenesis of abnormal venous wall composition but not of decreased venous capacity in renal hypertensive rats.

Related collections

Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1978

Publication date (Print): 1978

Publication date (Electronic): 18 September 2008

Volume: 15

Issue: 5

Pages: 311-321

Affiliations

Hypertension Section, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich.; Department of Medicine, University of Minnesota Hospitals, and Veterans Administration Hospital, Minneapolis, Minn.

Article

Publisher ID: 158176 Other ID: Blood Vessels 1978;15:311–321

DOI: 10.1159/000158176

SO-VID: 1a04ef8d-1836-4aeb-84f3-f2e8c954e23e

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 28 July 1977

Date accepted : 03 November 1977

Page count

Pages: 11

Comments

Comment on this article

scite_