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Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis.
Wendy C Moore
1 ,
Annette T Hastie
2 ,
Xingnan Li
2 ,
Huashi Li
2 ,
William W Busse
3 ,
Nizar N Jarjour
3 ,
Sally E Wenzel
4 ,
Stephen P Peters
2 ,
Deborah A Meyers
2 ,
Eugene R Bleecker
2
Jun 2014
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Abstract
Clinical cluster analysis from the Severe Asthma Research Program (SARP) identified 5 asthma subphenotypes that represent the severity spectrum of early-onset allergic asthma, late-onset severe asthma, and severe asthma with chronic obstructive pulmonary disease characteristics. Analysis of induced sputum from a subset of SARP subjects showed 4 sputum inflammatory cellular patterns. Subjects with concurrent increases in eosinophil (≥2%) and neutrophil (≥40%) percentages had characteristics of very severe asthma.