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      Point-of-care technologies for molecular diagnostics using a drop of blood.

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          Abstract

          Molecular diagnostics is crucial for prevention, identification, and treatment of disease. Traditional technologies for molecular diagnostics using blood are limited to laboratory use because they rely on sample purification and sophisticated instruments, are labor and time intensive, expensive, and require highly trained operators. This review discusses the frontiers of point-of-care (POC) diagnostic technologies using a drop of blood obtained from a finger prick. These technologies, including emerging biotechnologies, nanotechnologies, and microfluidics, hold the potential for rapid, accurate, and inexpensive disease diagnostics.

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          Author and article information

          Journal
          Trends Biotechnol.
          Trends in biotechnology
          1879-3096
          0167-7799
          Mar 2014
          : 32
          : 3
          Affiliations
          [1 ] Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA.
          [2 ] Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78758, USA.
          [3 ] Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX 77030, USA; Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY 10065, USA. Electronic address: Lqin@HoustonMethodist.org.
          Article
          S0167-7799(14)00004-3 NIHMS556498
          10.1016/j.tibtech.2014.01.003
          24525172
          1a23079a-8d42-44b0-849a-8407f87c2047
          Copyright © 2014 Elsevier Ltd. All rights reserved.
          History

          biomolecules,circulating tumor cells,molecular diagnostics,nucleic acids,point-of-care diagnostics,proteins

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