+1 Recommend
0 collections
      • Record: found
      • Abstract: found
      • Article: not found

      The FOXC2 C-512T polymorphism is associated with obesity and dyslipidemia.

      Obesity research
      Abdomen, Adipose Tissue, Adult, Alleles, Body Composition, Case-Control Studies, DNA-Binding Proteins, genetics, Female, Forkhead Transcription Factors, Heterozygote, Humans, Hyperlipidemias, Insulin Resistance, Logistic Models, Male, Middle Aged, Obesity, Odds Ratio, Polymorphism, Genetic, RNA, Messenger, analysis, Risk Factors, Transcription Factors, Triglycerides, blood

      Read this article at

          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.


          The transcription factor FOXC2 has been implicated in resistance to diet-induced obesity and insulin resistance. To investigate the possible role for FOXC2 in obesity and related phenotypes, we performed two association studies for obesity using unrelated case-control materials by genotyping the FOXC2 C-512T polymorphism. In the first study (127 obese and 127 normal-weight nondiabetic subjects matched for age and sex), the C-allele showed association with obesity, odds ratio 1.74 (1.12 to 2.73; p < 0.01) for the C- vs. T-allele and 1.81 (1.04 to 3.25; p < 0.05) for the C/C and C/T vs. T/T genotype. BMI was higher in carriers of the C/C and C/T genotype in normal weight [adjusted p value (p(adj)) = 0.02] but not in obese subjects (p(adj) = 0.1). In the replication study (223 obese and 231 nonobese subjects), subjects with the C/C genotype exhibited an increased risk for obesity, odds ratio 2.01 (1.15 to 3.52; p = 0.01). Obese carriers of the C-allele had lower high-density lipoprotein-cholesterol [1.1 (0.9 to 1.3) vs. 1.2 (1.0 to 1.4) mM, p(adj) = 0.006] and increased triglyceride levels (1.95 [1.30 to 2.68] vs. 1.60 [1.10 to 2.40] mM, p(adj) = 0.02) compared with obese carriers of the T/T genotype. Our data suggest that FOXC2 is a weak but consistent candidate gene for obesity and dyslipidemia.

          Related collections

          Author and article information


          Comment on this article