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      Role of the Hypothalamic TRH in the Regulation of Its Own Receptors in Rat Anterior Pituitaries

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          We explored whether endogenous TRH in the hypothalamus produced a potential change in its receptors in the rat anterior pituitary. Thyroidectomy caused a progressive increase in the pituitary TRH binding with a concomitant increase in the blood TSH level. Injection of T<sub>4 </sub>prevented the increase in the pituitary TRH binding and the blood TSH level after thyroidectomy. The hypothalamic deafferentation and electrolytic lesions in the hypothalamic paraventricular nuclei led to a significant reduction in both the content of TRH in the hypothalamic median eminence and the blood TSH level, but they affected neither the number nor affinity constant of the pituitary TRH receptors in thyroidectomized rats. The present data provide evidence that TRH receptors in the anterior pituitary are profoundly regulated by thyroid hormones, but not significantly by TRH in the hypothalamus in the rat.

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          Author and article information

          S. Karger AG
          02 April 2008
          : 48
          : 2
          : 153-159
          First Department of Internal Medicine, Gunma University, School of Medicine, Maebashi, Japan
          125003 Neuroendocrinology 1988;48:153–159
          © 1988 S. Karger AG, Basel

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          Pages: 7
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