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      A compendium of RNA-binding motifs for decoding gene regulation.

      Nature

      metabolism, Autistic Disorder, genetics, Base Sequence, Binding Sites, Conserved Sequence, Eukaryotic Cells, Gene Expression Regulation, Humans, Molecular Sequence Data, Nucleotide Motifs, Protein Structure, Tertiary, RNA Stability, RNA-Binding Proteins, chemistry

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          Abstract

          RNA-binding proteins are key regulators of gene expression, yet only a small fraction have been functionally characterized. Here we report a systematic analysis of the RNA motifs recognized by RNA-binding proteins, encompassing 205 distinct genes from 24 diverse eukaryotes. The sequence specificities of RNA-binding proteins display deep evolutionary conservation, and the recognition preferences for a large fraction of metazoan RNA-binding proteins can thus be inferred from their RNA-binding domain sequence. The motifs that we identify in vitro correlate well with in vivo RNA-binding data. Moreover, we can associate them with distinct functional roles in diverse types of post-transcriptional regulation, enabling new insights into the functions of RNA-binding proteins both in normal physiology and in human disease. These data provide an unprecedented overview of RNA-binding proteins and their targets, and constitute an invaluable resource for determining post-transcriptional regulatory mechanisms in eukaryotes.

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          Author and article information

          Journal
          23846655
          3929597
          10.1038/nature12311

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