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      Reperfusion-Induced Arrhythmias Are Suppressed by Inhibition of the Angiotensin II Type 1 Receptor

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          We examined antiarrhythmic effects of drugs, including renin-angiotensin system (RAS) inhibitors, on reperfusion arrhythmias in rats in vivo. Anesthetized rats were subjected to 5 min of coronary occlusion and 30 min of reperfusion. Arrhythmia scores, calculated as the product of the type of arrhythmia (1 for ventricular tachycardia, 2 for ventricular fibrillation) and its duration (in seconds), were adopted to evaluate the severity of arrhythmias. Reperfusion arrhythmias were suppressed by Na<sup>+</sup>/H<sup>+</sup> exchange inhibitor, Na<sup>+</sup>/Ca<sup>2+</sup> exchange inhibitor and L-type Ca channel antagonist by more than 90%. Angiotensin-converting enzyme inhibitor and angiotensin II (Ang II) type 1 receptor (AT<sub>1</sub>) antagonist also modestly (by 60–70%) but significantly decreased reperfusion arrhythmias. These effects were not reversed by co-administration of bradykinin B<sub>2</sub> receptor antagonist or AT<sub>2</sub> antagonist, respectively. Effects of superoxide dismutase (SOD) were also examined, but SOD proved ineffective. Effects of Na<sup>+</sup>/H<sup>+</sup> exchange inhibitor, Na<sup>+</sup>/Ca<sup>2+</sup> exchange inhibitor and L-type Ca channel antagonist suggest a causative relationship of Ca overload in reperfusion arrhythmias. These transport systems are known to be activated by Ang II. Thus, the antiarrhythmic action of RAS inhibitors might be attributable to the inhibition of the action of Ang II via AT<sub>1</sub>.

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          ISIS-4: A randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction

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            Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure

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                Author and article information

                S. Karger AG
                April 2003
                25 April 2003
                : 99
                : 2
                : 61-67
                Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan
                69722 Cardiology 2003;99:61–67
                © 2003 S. Karger AG, Basel

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                Page count
                Figures: 2, Tables: 1, References: 38, Pages: 7
                General Cardiology – Basic Science


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