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Pseudotyped adeno-associated viral vectors for gene transfer in dermal fibroblasts: implications for wound-healing applications
Swathi Balaji ,
Alice King ,
Yashu Dhamija ,
Louis D. Le ,
Aimen F. Shaaban ,
Timothy M. Crombleholme ,
Sundeep G. Keswani
September 2013
September 2013
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Abstract
Cell-specific gene transfer and sustained transgene expression are goals of cutaneous
gene therapy. Pseudotyping strategy with adeno-associated viral (AAV) vectors has
the potential to confer unique cellular tropism and transduction efficiency. We hypothesize
that pseudotyped AAV vectors have differential tropism and transduction efficiency
under normal and wound conditions in dermal fibroblasts.