12
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      GPCR-specific autoantibody signatures are associated with physiological and pathological immune homeostasis

      research-article
      1 , 2 , , 1 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 1 , 1 , 1 , 1 , 1 , 1 , 1 , 10 , 11 , 12 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 19 , 23 , 24 , 25 , 25 , 14 , 5 , 26 , 27 , 28 , 1 , 1 , 16 , 1 ,
      Nature Communications
      Nature Publishing Group UK

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Autoantibodies have been associated with autoimmune diseases. However, studies have identified autoantibodies in healthy donors (HD) who do not develop autoimmune disorders. Here we provide evidence of a network of immunoglobulin G (IgG) autoantibodies targeting G protein-coupled receptors (GPCR) in HD compared to patients with systemic sclerosis, Alzheimer’s disease, and ovarian cancer. Sex, age and pathological conditions affect autoantibody correlation and hierarchical clustering signatures, yet many of the correlations are shared across all groups, indicating alterations to homeostasis. Furthermore, we identify relationships between autoantibodies targeting structurally and functionally related molecules, such as vascular, neuronal or chemokine receptors. Finally, autoantibodies targeting the endothelin receptor type A (EDNRA) exhibit chemotactic activity, as demonstrated by neutrophil migration toward HD-IgG in an EDNRA-dependent manner and in the direction of IgG from EDNRA-immunized mice. Our data characterizing the in vivo signatures of anti-GPCR autoantibodies thus suggest that they are a physiological part of the immune system.

          Abstract

          Autoantibodies are implicated in autoimmunity, but may also be present in healthy individuals. Here the authors find that the autoantibody specificity signatures against various G protein-coupled receptors are associated with multiple parameters, including disease states, to imply a physiological function in maintaining immune homeostasis.

          Related collections

          Most cited references45

          • Record: found
          • Abstract: found
          • Article: not found

          Gene Ontology: tool for the unification of biology

          Genomic sequencing has made it clear that a large fraction of the genes specifying the core biological functions are shared by all eukaryotes. Knowledge of the biological role of such shared proteins in one organism can often be transferred to other organisms. The goal of the Gene Ontology Consortium is to produce a dynamic, controlled vocabulary that can be applied to all eukaryotes even as knowledge of gene and protein roles in cells is accumulating and changing. To this end, three independent ontologies accessible on the World-Wide Web (http://www.geneontology.org) are being constructed: biological process, molecular function and cellular component.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            The danger model: a renewed sense of self.

            For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Social network architecture of human immune cells unveiled by quantitative proteomics

              Immune cells give rise to the most interconnected system in the body. Meissner and colleagues perform comprehensive proteomics and secretomics to describe in detail the ‘social network’ of human immune cells and throw light on previously unknown cell connectivities.
                Bookmark

                Author and article information

                Contributors
                +49 1578 7209279 , otavio.cmarques@gmail.com
                +49 (0)451 500 2368 , gabriela.riemekasten@uksh.de
                Journal
                Nat Commun
                Nat Commun
                Nature Communications
                Nature Publishing Group UK (London )
                2041-1723
                6 December 2018
                6 December 2018
                2018
                : 9
                : 5224
                Affiliations
                [1 ]ISNI 0000 0001 0057 2672, GRID grid.4562.5, Department of Rheumatology and Clinical Immunology, , University of Lübeck, ; Lübeck, 23538 Germany
                [2 ]GRID grid.5963.9, Department of Rheumatology and Clinical Immunology, Center for Chronic Immunodeficiency (CCI), Medical Center-University of Freiburg, Faculty of Medicine, , University of Freiburg, ; Freiburg, 79106 Germany
                [3 ]ISNI 0000 0001 0670 7996, GRID grid.411227.3, Department of Statistic, , Federal University of Pernambuco, ; Recife, PE 50670-901 Brazil
                [4 ]ISNI 0000 0004 1936 7443, GRID grid.7914.b, Deaconess Hospital, , University of Bergen, ; 5006 Bergen, Norway
                [5 ]ISNI 0000 0001 2097 5006, GRID grid.16750.35, Department of Computer Science, , Princeton University, ; Princeton, NJ 08540 USA
                [6 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Department of Gastroenterology, Infectiology and Rheumatology, , Charité University Hospital, ; Berlin, 12203 Germany
                [7 ]GRID grid.484013.a, Berlin Institute of Health (BIH), ; Berlin, 10178 Germany
                [8 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Dept. of Rheumatology and Clinical Immunology, , Charité University Hospital, ; Berlin, 10117 Germany
                [9 ]ISNI 0000 0000 9323 8675, GRID grid.418217.9, Cell Autoimmunity Group, , German Rheumatism Research Center (DRFZ), ; Berlin, 10117 Germany
                [10 ]ISNI 0000 0001 0726 5157, GRID grid.5734.5, University Hospital and University of Bern, ; Bern, 3012 Switzerland
                [11 ]ISNI 0000 0001 1014 0849, GRID grid.419491.0, Experimental and Clinical Research Center, a collaboration of Max Delbruck Center for Molecular Medicine and Charité Universitätsmedizin, ; Berlin, 13125 Germany
                [12 ]ISNI 0000 0001 0549 9953, GRID grid.418468.7, Department of Cardiology and Nephrology, , HELIOS-Klinikum Berlin, ; Berlin, 13125 Germany
                [13 ]GRID grid.484013.a, Berlin Institute of Health (BIH), ; Berlin, 10178 Germany
                [14 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Department of Nephrology and Cardiovascular Research, Campus Virchow, , Charité University Hospital, ; Berlin, 13353 Germany
                [15 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Department of Gynecology, , Charité University Hospital, Berlin and Tumor Bank Ovarian Cancer Network (TOC), ; Berlin, 13353 Germany
                [16 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Department of Urology, , Charité University Hospital, ; Berlin, 10117 Germany
                [17 ]CellTrend GmbH, Luckenwalde, 14943 Germany
                [18 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Dept. of Internal Medicine & Cardiology, , Charité University Hospital, ; Berlin, 13353 Germany
                [19 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Institute for Medical Immunology, , Charité University Hospital Berlin, ; Campus Virchow, Berlin, 10117 Germany
                [20 ]ISNI 0000 0001 2218 4662, GRID grid.6363.0, Berlin-Brandenburg Center for Regenerative Therapies (BCRT), , Charité University Hospital Berlin, ; Berlin, 13353 Germany
                [21 ]ISNI 0000 0004 1936 8921, GRID grid.5510.1, University of Oslo and Oslo University Hospital, ; 0372 Oslo, Norway
                [22 ]ISNI 0000 0001 1018 4307, GRID grid.5807.a, University Clinic for Nephrology and Hypertension, Diabetes and Endocrinology, , Otto-von-Guericke University Magdeburg, ; Magdeburg, 39106 Germany
                [23 ]GRID grid.5963.9, Department of Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, , Albert Ludwigs University (ALU) of Freiburg, ; Freiburg, 79106 Germany
                [24 ]GRID grid.5963.9, Faculty of Biology, , Albert-Ludwigs-University (ALU), ; Freiburg, 79104 Germany
                [25 ]ISNI 0000 0001 0057 2672, GRID grid.4562.5, Section Experimental Oncology, University Hospital and Medical School (UKSH), , University of Lübeck, ; Lübeck, 23538 Germany
                [26 ]ISNI 0000 0001 2193 6666, GRID grid.43519.3a, Department of Biochemistry College of Medicine and Health Sciences, , UAE University, ; Al Ain, 17666 United Arab Emirates
                [27 ]ISNI 0000 0000 9026 4165, GRID grid.240741.4, Department of Pediatrics, University of Washington School of Medicine, , Seattle Children’s Research Institute, ; Seattle, WA 98191 USA
                [28 ]ISNI 0000 0001 2193 6666, GRID grid.43519.3a, Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, , UAE University, ; Al Ain, 17666 United Arab Emirates
                Author information
                http://orcid.org/0000-0001-8309-2112
                http://orcid.org/0000-0002-1340-7526
                http://orcid.org/0000-0002-6139-7334
                Article
                7598
                10.1038/s41467-018-07598-9
                6283882
                30523250
                1a487cde-e20c-4630-998c-2d2fee8b44a8
                © The Author(s) 2018

                Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

                History
                : 21 May 2018
                : 7 November 2018
                Categories
                Article
                Custom metadata
                © The Author(s) 2018

                Uncategorized
                Uncategorized

                Comments

                Comment on this article