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      Amyloid Burden in Obstructive Sleep Apnea.

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          Abstract

          To test the hypothesis that excessive amyloid deposition is a biological link between obstructive sleep apnea (OSA) and Alzheimer's disease, we determined whether OSA increases cerebral amyloid burden, relative to controls, using Pittsburgh Compound B (PiB) PET imaging. The subjects were adult participants (age 50-65 years) from the Korean Genome and Epidemiology Study. Polysomnography, brain MRI including 3D images, and a detailed neuro-cognitive function test battery were done in 2011-2012. Nineteen OSA subjects (Apnea-Hypopnea Index [AHI] ≥15/h, 21.2±5.1/h; age 58.5±4.1 years; 9 male) and 19 controls (AHI 1.8±1.3/h; age 58.5±4.2 years; 9 male) underwent 60-min dynamic 11C-PiB PET. All subjects were right-handed with normal cognitive function and brain MRI. Controls were matched by age, gender, education, and APOE genotype. A voxel-wise comparison of PiB-PET images between the two groups was performed after spatial and count normalization with cerebellar gray matter as a reference. Covariates included the status of sleep duration, hypertension, diabetes, body mass index, exercise, depressive mood, smoking, and alcohol drinking. Cortical thickness on 3D MRI was also measured and compared between the two groups. The OSA group showed a higher PiB deposition in the right posterior cingulate gyrus and right temporal cortex (corrected p < 0.05). There was no area of higher uptake in the control compared with OSA. Regional differences in cortical thickness were not significant. The study suggests that OSA accelerates amyloid deposition and may contribute to the development or progression of Alzheimer's disease.

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          Author and article information

          Journal
          J. Alzheimers Dis.
          Journal of Alzheimer's disease : JAD
          IOS Press
          1875-8908
          1387-2877
          May 26 2017
          Affiliations
          [1 ] Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
          [2 ] Department of Nuclear Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
          [3 ] Institute of Human Genomic Study, Korea University Ansan Hospital, Ansan, Republic of Korea.
          [4 ] Department of Psychological and Brain Sciences, Boston University, Boston, MA, USA.
          [5 ] Departmentof Radiology, Korea University Ansan Hospital, Ansan, Republic ofKorea.
          [6 ] Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, and Center for Nanomolecular Imagingand Innovative Drug Development, Advanced Institutes ofConvergence Technology, Suwon, Republic of Korea.
          [7 ] Department of Radiology, Athinoula A. MartinosCenter for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
          [8 ] Departments of Anatomy and Neurobiology, Neurology and Epidemiology, Schools of Medicine and Public Health, Boston University, Boston, MA, USA.
          [9 ] Departmentof Internal Medicine, Division of Pulmonary, Sleep and CriticalCare Medicine, Korea University Ansan Hospital, Ansan, Republic ofKorea.
          [10 ] Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, USA.
          Article
          JAD161047
          10.3233/JAD-161047
          28550245
          1a4d61ce-fd3c-4841-941e-0b9bfb4c351f

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