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      Measurement of Coronary Blood Flow and Flow Reserve Using Magnetic Resonance Imaging

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          Abstract

          Purpose: It was the purpose of this study to demonstrate the feasibility of performing coronary artery flow and coronary flow reserve (CFR) measurements in normal human volunteers using a magnetic resonance (MR) phase contrast technique. Materials and Methods: Coronary flow rate, flow velocity, peak flow and CFR were determined at rest and during pharmacologically induced hyperemia in 10 healthy volunteers. The flow measurements were obtained during a single breath-hold by using a fast, prospectively gated, segmented k-space gradientecho phase contrast acquisition with view sharing (FAST-CARD PC) that was modified to improve sampling of the diastolic flow. Data were processed using the standard phase difference (PD) processing techniques as well as a new complex difference (CD) flow measurement method intended to improve the accuracy of flow measurements in small vessels. Results: Mean hyperemic flow velocity (40 ± 16 cm/s) and blood flow (3.9 ± 1.5 m1/s) rates differed significantly from resting velocity (13 ± 6.6 cm/s) and flow (1.1 ± 0.4 ml/s) measurements (p < 0.0001). PD methods consistently measured larger flow rates at rest (24% larger, p < 0.0005) and stress (29% larger, p < 0.0001). CFR, calculated as the ratio of the mean PD flows (4.7 ± 2.8), was higher than CFR calculated as the ratio of mean CD flows (4.2 ± 1.8); however, the differences did not reach statistical significance (p = 0.07). Flow measurements performed in adjacent slices of the same vessel correlated well (r = 0.88). Conclusions: Coronary flow and CFR measurements using the MR techniques are feasible and are similar to those reported in the literature for healthy volunteers.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1997
          1997
          19 November 2008
          : 88
          : 1
          : 80-89
          Affiliations
          Departments of aRadiology, bCardiology and cMedical Physics, University of Wisconsin Medical School, Madison, Wisc., and dGeneral Electric Medical Systems, Milwaukee, Wisc., USA
          Article
          177314 Cardiology 1997;88:80–89
          10.1159/000177314
          8960630
          © 1997 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 10
          Categories
          Myocardial Blood Flow Symposium

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