Regulation network and expression profiles of Epstein-Barr virus-encoded microRNAs and their potential target host genes in nasopharyngeal carcinomas.

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Abstract

Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC) tumorigenesis. However, the mechanism(s) connecting EBV infection and NPC remain unclear. Recently, a new class of EBV microRNAs (miRNAs) has been described. To determine how EBV miRNAs control the expression of host genes, and to understand their potential role in NPC tumorigenesis, we profiled the expression of 44 mature EBV miRNAs and potential host genes in NPC and non-tumor nasopharyngeal epithelial tissues. We found that 40 EBV miRNAs from the BART transcript were highly expressed in NPC. Analysis of potential BART miRNA target genes revealed that 3140 genes and several important pathways might be involved in the carcinogenesis of NPC. A total of 105 genes with potential EBV miRNA binding sites were significantly downregulated, suggesting that EBV miRNAs may regulate these genes and contribute to NPC carcinogenesis. An EBV miRNA and host gene regulation network was generated to provide useful clues for validating of EBV miRNA functions in NPC tumorigenesis.

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Journal

Journal ID (iso-abbrev): Sci China Life Sci

Title: Science China. Life sciences

Publisher: Springer Science and Business Media LLC

ISSN (Electronic): 1869-1889

ISSN (Print): 1674-7305

Publication date (Electronic): Mar 2014

Volume: 57

Issue: 3

Affiliations

[1 ] Hunan Provincial Tumor Hospital, Xiangya School of Medicine, Central South University, Changsha, 410013, China.

[2 ] Key Laboratory of Carcinogenesis of Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, China.

[3 ] Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, China.

[4 ] Key Laboratory of Information System Engineering, National University of Defense Technology, Changsha, 410073, China.

[5 ] Department of Biochemistry and Molecular Biology and Center for Genetics and Molecular Medicine, School of Medicine, University of Louisville, Louisville, KY, 40202, USA.

[6 ] Hunan Provincial Tumor Hospital, Xiangya School of Medicine, Central South University, Changsha, 410013, China. xiongwei@xysm.net.

[7 ] Key Laboratory of Carcinogenesis of Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, China. xiongwei@xysm.net.

[8 ] Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. xiongwei@xysm.net.

[9 ] Hunan Provincial Tumor Hospital, Xiangya School of Medicine, Central South University, Changsha, 410013, China. ligy@xysm.net.

[10 ] Key Laboratory of Carcinogenesis of Ministry of Health, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Cancer Research Institute, Central South University, Changsha, 410078, China. ligy@xysm.net.

[11 ] Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Disease Genome Research Center, The Third Xiangya Hospital, Central South University, Changsha, 410013, China. ligy@xysm.net.

Article

Publisher Item ID: 10.1007/s11427-013-4577-y

DOI: 10.1007/s11427-013-4577-y

PubMed ID: 24532457

SO-VID: 1a69de6b-18d3-4497-b0a8-ba4c1da8e20a

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