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Abstract
<p class="first" id="P1">Although the clinical demand for bioengineered blood vessels
continues to rise, current
options for vascular conduits remain limited. The synergistic combination of emerging
advances in tissue fabrication and stem cell engineering promises new strategies for
engineering autologous blood vessels that recapitulate not only the mechanical properties
of native vessels but also their biological function. Here we explore recent bioengineering
advances in creating functional blood macro and microvessels, particularly featuring
stem cells as a seed source. We also highlight progress integrating engineered vascular
tissues with the host following implantation, as well as the exciting pre-clinical
and clinical applications of this technology.
</p>