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      Adverse drug events in the outpatient setting: an 11-year national analysis.

      Pharmacoepidemiology and Drug Safety

      Young Adult, United States, Sex Factors, Risk Factors, Retrospective Studies, Polypharmacy, statistics & numerical data, Outpatients, National Center for Health Statistics (U.S.), Multivariate Analysis, Middle Aged, Male, Infant, Humans, Hospitalization, Female, Drug-Related Side Effects and Adverse Reactions, Child, Preschool, Child, Aged, Age Factors, Adult, Adolescent

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          Abstract

          Adverse drug events (ADEs) are a common complication of medical care resulting in high morbidity and medical expenditure. Population level estimates of outpatient ADEs are limited. Our objective was to provide national estimates and characterizations of outpatient ADEs and determine risk factors associated with these events. Data are from the National Center for Health Statistics which collects information on patient visits to outpatient clinics and emergency departments throughout the United States. We examined visits between 1995 and 2005 and measured the national annual estimates of and risk factors for outpatient ADEs requiring medical treatment. The national annual number of ADE-related visits was 4 335,990 (95%CI: 4 326 872-4 345 108). Visits for ADEs to outpatient clinics increased over the study period from 9.0 to 17.0 per 1000 persons (p-value for trend < 0.001). In multivariate analyses, factors associated with ADE visits included patient age (OR: 2.13; 95%CI: 1.63-2.79 for 65 years and older), number of medications taken by patient (OR: 1.88; 95%CI: 1.58-2.25 for five medications or more), and female gender (OR: 1.51; 95%CI: 1.34-1.71). Overall, outpatient ADEs resulted in 107,468 (95%CI: 89 011-125 925) hospital admissions annually, with older patients at highest risk for hospitalization (p-value for trend < 0.001). Both patient age and polypharmacy use are risk factors for ADE-related healthcare visits, which have substantially increased in outpatient clinics between 1995 and 2005. The incidence of ADEs has particularly increased among patients 65 years and older with as many as 1 in 20 persons seeking medical care for an ADE. (c) 2010 John Wiley & Sons, Ltd.

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          Journal
          20623513
          2932855
          10.1002/pds.1984

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