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      Primary ovarian insufficiency: a more accurate term for premature ovarian failure.

      Clinical Endocrinology
      Female, Humans, Primary Ovarian Insufficiency, etiology, genetics, physiopathology

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          Abstract

          Premature ovarian failure (POF) is a disorder with a complicated clinical presentation and course that is poorly defined by its name. A more scientifically accurate term for the disorder is primary ovarian insufficiency (POI), a term that can be appropriately modified to describe the state of ovarian function. In recent years, the known aetiologies of POI have expanded, although the cause of POI in a majority of clinical cases remains undefined. The most common aetiologies should be ruled out clinically including chromosomal abnormalities, fragile X premutations and autoimmune causes. Management should be directed at symptom resolution and bone protection, but most importantly should include psychosocial support for women facing this devastating diagnosis.

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          Author and article information

          Journal
          17970776
          10.1111/j.1365-2265.2007.03073.x

          Chemistry
          Female,Humans,Primary Ovarian Insufficiency,etiology,genetics,physiopathology
          Chemistry
          Female, Humans, Primary Ovarian Insufficiency, etiology, genetics, physiopathology

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