Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.

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Abstract

Intra-articularly injected monosodium iodoacetate (MIA) induces joint pathology mimicking osteoarthritis (OA) and it is a widely used experimental model of OA. MIA induces acute inflammation, cartilage degradation and joint pain. Transient Receptor Potential Ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation. Here, we tested the hypothesis that TRPA1 would be involved in the development of MIA-induced acute inflammation, cartilage changes and joint pain.

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Journal

Journal ID (iso-abbrev): Osteoarthr. Cartil.

Title: Osteoarthritis and cartilage

Publisher: Elsevier BV

ISSN (Electronic): 1522-9653

ISSN (Print): 1063-4584

Publication date (Electronic): Nov 2015

Volume: 23

Issue: 11

Affiliations

[1 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: lauri.j.moilanen@uta.fi.

[2 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: mari.j.hamalainen@uta.fi.

[3 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: elina.nummenmaa@uta.fi.

[4 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: pinja.ilmarinen@uta.fi.

[5 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: katriina.vuolteenaho@uta.fi.

[6 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: riina.m.nieminen@uta.fi.

[7 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: lauri.lehtimaki@uta.fi.

[8 ] The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland. Electronic address: eeva.moilanen@uta.fi.

Article

Publisher Item ID: S1063-4584(15)01322-9

DOI: 10.1016/j.joca.2015.09.008

PubMed ID: 26521748

SO-VID: 1aa95b56-39fd-43df-b3bb-736fb741fb7f

History

Keywords: COX-2,Inflammation,Joint pain,Monosodium iodoacetate-induced osteoarthritis,TRPA1

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Keywords: COX-2, Inflammation, Joint pain, Monosodium iodoacetate-induced osteoarthritis, TRPA1

Monosodium iodoacetate-induced inflammation and joint pain are reduced in TRPA1 deficient mice--potential role of TRPA1 in osteoarthritis.

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