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      Histamine-Induced Constriction and Dilatation of Rabbit Middle Cerebral Arteries in vitro: Role of the Endothelium

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          Abstract

          We studied the effects of histamine on perfused rabbit middle cerebral arteries in vitro. Intact and endothelium-denuded preparations were compared. Histamine caused concentration-dependent constrictions in intact vessels which were competitively inhibited by an H<sub>1</sub> receptor antagonist. This constriction was potentiated by either H<sub>2</sub>-receptor blockade or endothelium denudation. The greatest potentiation was observed with intraluminal as opposed to extraluminal administration. The H<sub>1</sub> receptor agonist pyridylethylamine induced similar concentration-dependent constriction in intact and denuded preparations. After pre-constriction, histamine, in the presence of an H<sub>1</sub> receptor antagonist, dilated intact vessels to a maximum of 45.1 %, and endothelium-denuded vessels to a maximum of 22% (p < 0.02). We conclude that rabbit middle cerebral arteries possess H<sub>1</sub> constrictory and H<sub>2</sub> dilatory receptors, and that many of the H<sub>2</sub> dilatory receptors are situated on the endothelial cells.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1986
          1986
          12 November 2008
          : 23
          : 3
          : 137-153
          Affiliations
          aLaboratoire de Physiologie et Physiopathologie Cérébrovasculaire, U-182 Inserm, Université Paris VII, CNRS UA 641, Paris; bLaboratoire de Pharmacologie, UER de Médecine et Pharmacie, Limoges; cLaboratoire de Cytologie, Université Paris VI, CNRS UA 558, Paris, France
          Article
          158632 Blood Vessels 1986;23:137–153
          10.1159/000158632
          © 1986 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 17
          Categories
          Research Paper

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