Histamine-Induced Constriction and Dilatation of Rabbit Middle Cerebral Arteries in vitro: Role of the Endothelium

There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

Abstract

We studied the effects of histamine on perfused rabbit middle cerebral arteries in vitro. Intact and endothelium-denuded preparations were compared. Histamine caused concentration-dependent constrictions in intact vessels which were competitively inhibited by an H1 receptor antagonist. This constriction was potentiated by either H2-receptor blockade or endothelium denudation. The greatest potentiation was observed with intraluminal as opposed to extraluminal administration. The H1 receptor agonist pyridylethylamine induced similar concentration-dependent constriction in intact and denuded preparations. After pre-constriction, histamine, in the presence of an H1 receptor antagonist, dilated intact vessels to a maximum of 45.1 %, and endothelium-denuded vessels to a maximum of 22% (p < 0.02). We conclude that rabbit middle cerebral arteries possess H1 constrictory and H2 dilatory receptors, and that many of the H2 dilatory receptors are situated on the endothelial cells.

Related collections

Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1986

Publication date (Print): 1986

Publication date (Electronic): 12 November 2008

Volume: 23

Issue: 3

Pages: 137-153

Affiliations

^aLaboratoire de Physiologie et Physiopathologie Cérébrovasculaire, U-182 Inserm, Université Paris VII, CNRS UA 641, Paris; ^bLaboratoire de Pharmacologie, UER de Médecine et Pharmacie, Limoges; ^cLaboratoire de Cytologie, Université Paris VI, CNRS UA 558, Paris, France

Article

Publisher ID: 158632 Other ID: Blood Vessels 1986;23:137–153

DOI: 10.1159/000158632

SO-VID: 1ab08e60-a48f-46bb-8180-67d94f4a270e

License:

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 19 November 1985

Date accepted : 13 February 1986

Page count

Pages: 17

Comments

Comment on this article

scite_