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      Histamine-Induced Constriction and Dilatation of Rabbit Middle Cerebral Arteries in vitro: Role of the Endothelium


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          We studied the effects of histamine on perfused rabbit middle cerebral arteries in vitro. Intact and endothelium-denuded preparations were compared. Histamine caused concentration-dependent constrictions in intact vessels which were competitively inhibited by an H<sub>1</sub> receptor antagonist. This constriction was potentiated by either H<sub>2</sub>-receptor blockade or endothelium denudation. The greatest potentiation was observed with intraluminal as opposed to extraluminal administration. The H<sub>1</sub> receptor agonist pyridylethylamine induced similar concentration-dependent constriction in intact and denuded preparations. After pre-constriction, histamine, in the presence of an H<sub>1</sub> receptor antagonist, dilated intact vessels to a maximum of 45.1 %, and endothelium-denuded vessels to a maximum of 22% (p < 0.02). We conclude that rabbit middle cerebral arteries possess H<sub>1</sub> constrictory and H<sub>2</sub> dilatory receptors, and that many of the H<sub>2</sub> dilatory receptors are situated on the endothelial cells.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          12 November 2008
          : 23
          : 3
          : 137-153
          aLaboratoire de Physiologie et Physiopathologie Cérébrovasculaire, U-182 Inserm, Université Paris VII, CNRS UA 641, Paris; bLaboratoire de Pharmacologie, UER de Médecine et Pharmacie, Limoges; cLaboratoire de Cytologie, Université Paris VI, CNRS UA 558, Paris, France
          158632 Blood Vessels 1986;23:137–153
          © 1986 S. Karger AG, Basel

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          Pages: 17
          Research Paper


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