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Abstract
<p id="P3">Human health is dependent upon environmental exposures, yet the diversity
and variation
in exposures is poorly understood. We developed a sensitive method to monitor personal
airborne biological and chemical exposures and followed the personal exposomes of
15 individuals for up to 890 days and over 66 distinct geographical locations. We
found that individuals are potentially exposed to thousands of pan-domain species
and chemical compounds, including insecticides and carcinogens. Personal biological
and chemical exposomes are highly dynamic and vary spatial-temporally, even for individuals
located in the same general geographical region. Integrated analysis of biological
and chemical exposomes revealed strong location-dependent relationships. Finally,
construction of an exposome interaction network demonstrated the presence of distinct
yet interconnected human- and environment-centric clouds, comprised of interacting
ecosystems such as human, flora, pets and arthropods. Overall, we demonstrate that
human exposomes are diverse, dynamic, spatiotemporally-driven interaction networks
with the potential to impact human health.
</p><p id="P4">
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<img alt="" class="figure" src="/document_file/f51d8d72-b909-4567-bb91-3f3719246dec/PubMedCentral/image/nihms-1507935-f0001.jpg"/>
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</p><p id="P5">Tracking personal exposure to airborne biological and chemical agents
enables construction
of an interaction network linking individuals, their geographic locations, and environmental
factors, which could have broad implications for human health.
</p>