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      Autoimmune Factors Associated with Infarction of the Kidney

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      Nephron

      S. Karger AG

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          Abstract

          The injection of normal or ínfarcted homologous renal tissue induced hypertension in the rat comparable to that which follows unilateral infarction of the kidney. The serum of such rats exhibited precipitin reactions against trypsinized digests of isologous kidney and arterial tissues. The presence of anti-kidney and anti-artery components in the serum was also indicated by the binding of fluorescein-conjugated globulins to the glomerular and basement membranes and arterial components of normal kidney. Globulin was localized in the small arteries of kidneys exhibiting endarteritis and damage to the elastic membrane. Suppressants of antibody reactions (cortisone and 6-mercaptopurine) inhibited the development of hypertension following infarction of the kidney. The demonstration of the presence of anti-kidney components in the sera of certain patients with hypertension and those with renal disease suggests that this phenomena of an autoimmune reaction against renal tissue which has been induced experimentally in the rat may also play a role in human disorders. When this process affects that part of the nephron normally concerned in the maintenance of the normotensive state, hypertension ensues.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          1964
          1964
          25 November 2008
          : 1
          : 2
          : 93-102
          Affiliations
          Department of Experimental Medicine, The University of Texas, Dallas, Texas
          Article
          179322 Nephron 1964;1:93–102
          10.1159/000179322
          14248727
          © 1964 S. Karger AG, Basel

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          Page count
          Pages: 10
          Categories
          Paper

          Cardiovascular Medicine, Nephrology

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