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      Furious Frederich: Nietzsche’s neurosyphilis diagnosis and new hypotheses Translated title: Frederico Furioso: O diagnóstico de neurossífilis de Nietzsche e novas hipóteses

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          Abstract

          The causes of Friedrich Nietzsche’s mental breakdown in early 1889 and of the subsequent slow decay to end-stage dementia along ten years will possibly remain open to debate. The diagnosis of syphilitic dementia paralytica, based only on medical anamnesis and physical examination, was considered indisputable by Otto Binswanger. On the other hand, taking into account recently described diseases, selectively collected evidence lend some support to alternative hypotheses: basal forebrain meningioma, CADASIL, MELAS and frontotemporal dementia.

          Translated abstract

          As causas da crise neuropsiquiátrica de Friedrich Nietzsche no início de 1889 e de sua lenta deterioração em demência avançada ao longo de 10 anos provavelmente permanecerão uma questão em aberto. O diagnóstico da época, demência paralítica sifilítica, foi considerado por Otto Binswanger como indiscutível. Por outro lado, em vista de novas doenças descritas, evidências seletivamente ordenadas sugerem diversas hipóteses alternativas propostas ao longo das últimas décadas, como meningioma frontal, CADASIL, MELAS e demência frontotemporal.

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          Most cited references 16

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          Friedrich Nietzsche (1844-1900): a classical case of mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS) syndrome?

           C Koszka (2009)
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            The neurological illness of Friedrich Nietzsche.

            Friedrich Nietzsche (1844-1900), one of the most profound and influential modern philosophers, suffered since his very childhood from severe migraine. At 44 he had a mental breakdown ending in a dementia with total physical dependence due to stroke. From the very beginning, Nietzsche's dementia was attributed to a neurosyphilitic infection. Recently, this tentative diagnosis has become controversial.
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              Clinical Psychiatry

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                Author and article information

                Contributors
                Role: ND
                Role: ND
                Journal
                anp
                Arquivos de Neuro-Psiquiatria
                Arq. Neuro-Psiquiatr.
                Academia Brasileira de Neurologia - ABNEURO (São Paulo )
                1678-4227
                December 2015
                : 73
                : 12
                : 1041-1043
                Affiliations
                [1 ] Universidade Federal do Rio de Janeiro Brazil
                [2 ] Sinapse Clínica Neurológica e Reabilitação Brazil
                [3 ] Universidade do Estado do Rio de Janeiro Brazil
                Article
                S0004-282X2015001201041
                10.1590/0004-282X20150164
                Product
                Product Information: website
                Categories
                NEUROSCIENCES
                PSYCHIATRY

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