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Single-particle tracking: applications to membrane dynamics.

Annual review of biophysics and biomolecular structure

methods, Microscopy, Video, metabolism, Membrane Proteins, Membrane Lipids, physiology, Membrane Fluidity, Humans, Diffusion

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      Abstract

      Measurements of trajectories of individual proteins or lipids in the plasma membrane of cells show a variety of types of motion. Brownian motion is observed, but many of the particles undergo non-Brownian motion, including directed motion, confined motion, and anomalous diffusion. The variety of motion leads to significant effects on the kinetics of reactions among membrane-bound species and requires a revision of existing views of membrane structure and dynamics.

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      Journal
      10.1146/annurev.biophys.26.1.373
      9241424
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