15
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Risk Factors for Suicidality in Patients With Schizophrenia: A Systematic Review, Meta-analysis, and Meta-regression of 96 Studies

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The lifetime risk of suicide and suicide attempt in patients with schizophrenia are 5% and 25%–50%, respectively. The current meta-analysis aims to determine risk factors associated with suicidality in subjects with schizophrenia. We searched Pubmed, Web of Science, EMBASE, and the reference lists of included studies. Inclusion criteria were met if an article reported a dichotomous sample of patients with schizophrenia with suicidal ideation, attempted suicide, or suicide compared to patients without. We also performed a cohort study meta-analysis as a supplemental analysis. A total of 96 studies with 80488 participants were included in our analysis. Depressive symptoms ( P < .0001), Positive and Negative Symptom Scale (PANSS) general score ( P < .0001) and number of psychiatric hospitalizations ( P < .0001) were higher in patients with suicide ideation. History of alcohol use ( P = .0001), family history of psychiatric illness ( P < .0001), physical comorbidity ( P < .0001), history of depression ( P < .0001), family history of suicide ( P < .0001), history of drug use ( P = .0024), history of tobacco use ( P = .0034), being white ( P = .0022), and depressive symptoms ( P < .0001) were the most consistent variables associated with suicide attempts. The first two were also significant in the cohort meta-analysis. Being male ( P = .0005), history of attempted suicide ( P < .0001), younger age ( P = .0266), higher intelligence quotient ( P < .0001), poor adherence to treatment ( P < .0001), and hopelessness ( P < .0001) were the most consistently associated with suicide. The first three were also significant in the cohort meta-analysis. Our findings may help with future development of preventive strategies to combat suicide. Future studies may combine the above-mentioned variables by using multivariate predictive analysis techniques to objectively stratify suicidality in schizophrenia.

          Related collections

          Author and article information

          Journal
          Schizophr Bull
          Schizophr Bull
          schbul
          Schizophrenia Bulletin
          Oxford University Press (US )
          0586-7614
          1745-1701
          June 2018
          23 September 2017
          06 June 2019
          : 44
          : 4
          : 787-797
          Affiliations
          [1 ]McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX
          [2 ]Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX
          [3 ]Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada
          [4 ]Bipolar Disorder Program and Laboratory of Molecular Psychiatry, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
          [5 ]Graduation Program in Psychiatry and Department of Psychiatry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil
          Author notes

          These authors contributed equally to the article.

          To whom correspondence should be addressed; Federal University of Rio Grande do Sul, Avenida Ramiro Barcelos, 2350, Porto Alegre-RS 90035–903, Brazil; tel: +55-512-101-8845, fax: +55 51 33598846, e-mail: ivescp1@ 123456gmail.com
          Article
          PMC6007264 PMC6007264 6007264 sbx131
          10.1093/schbul/sbx131
          6007264
          29036388
          1afa3cfa-36e0-4907-a691-e09155250185
          © The Author 2017. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oup.com

          This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model ( https://academic.oup.com/journals/pages/about_us/legal/notices)

          History
          Page count
          Pages: 11
          Funding
          Funded by: University of Texas Health Science Center at Houston 10.13039/100012615
          Award ID: 4TL1TR000369-10
          Categories
          Regular Articles

          suicide,meta-analysis,risk factors,schizophrenia
          suicide, meta-analysis, risk factors, schizophrenia

          Comments

          Comment on this article