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      Evaluation of the mutagenicity of antimalarial products isolated from Solanum nudum (Solanaceae).

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      Die Pharmazie

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          Abstract

          Diosgenone is a major component of the hexane extract from the plant Solanum nudum (Solanaceae). The products from degraded and acetylated diosgenone that showed in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum and methanol, dichloromethane and ethereal extracts of Solanum nudum were tested for their mutagenic activity using the Ames test with the TA-97a, TA-98, TA-100 and TA-102 strains of Salmonella typhimurium. These compounds were not mutagenic at the tested concentrations.

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          Author and article information

          Journal
          Pharmazie
          Die Pharmazie
          0031-7144
          0031-7144
          Apr 2003
          : 58
          : 4
          Affiliations
          [1 ] Malaria Group, University of Antioquia, Medellín, Colombia.
          Article
          12749410

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