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      Effect of orally administered alpha-tocopheryl acetate on human myocardial alpha-tocopherol levels

      , , ,
      Cardiovascular Drugs and Therapy
      Springer Nature America, Inc

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          Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?

          The concentration of lipid-soluble, chain-breaking antioxidants in human plasma and in erythrocyte ghosts have been determined for the first time by an inhibited-autoxidation method. The results are very similar to the concentrations of vitamin E measured for the same blood components by the HPLC method. It is concluded that vitamin E, which is largely present as alpha-tocopherol, is the only significant lipid-soluble, chain-breaking type of antioxidant present in human blood. The concentration of vitamin E in the plasma lipids divided by the concentration of vitamin E in the ghost membrane lipids is approximately a constant despite the large differences in vitamin E-intake and in plasma lipid concentrations in different individuals. Vitamin E/lipid ratios for plasma and ghosts were larger for subjects taking a supplement of alpha-tocopherol acetate of 100 IU per week, compared to nonsupplemented subjects (based on data from a limited number of subjects). A larger supplement of 2800 IU per week did not significantly increase the vitamin E/lipid ratios.
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            Measurement of coronary sinus blood flow by continuous thermodilution in man.

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              Biokinetics of and discrimination between dietaryRRR- andSRR-α-tocopherols in the male rat

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                Author and article information

                Journal
                Cardiovascular Drugs and Therapy
                Cardiovasc Drug Ther
                Springer Nature America, Inc
                0920-3206
                1573-7241
                March 1991
                March 1991
                : 5
                : S2
                : 309-312
                Article
                10.1007/BF00054753
                1b013457-1dc1-4e41-8928-abd3c3b87d50
                © 1991
                History

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